FEMS Microbiology LettersLatest Issue | Online Early | The Publisher | FEMSLE Editors
Chief Editor: Jeff Cole
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2009 IMPACT FACTOR: 2.199
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The host-infecting fungal transcriptome
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The capture of pathogen gene expression signatures directly from the host niche promises to fuel our understanding of the highly complex nature of microbial virulence. However, obtaining and interpreting biological information from infected tissues presents multiple experimental and intellectual challenges, from difficulties in extracting pathogen RNA and appropriate choice of experimental design, to interpretation of the resulting infection transcriptome, itself a product of responses to multiple host-derived cues. The recent publication of several host-infecting fungal transcriptomes offers new opportunities to study the commonalities of animal and ... Read more
Timothy Cairns, Florencia Minuzzi & Elaine Bignell
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FEMS Microbiology Letters offers rapid review and publication of outstanding research in all aspects of Microbiology, except virology (other than Bacteriophages).
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Highlight: Lactobacillus helveticus inhibits C. jejuni invasion of human cells. Wine et al.
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Campylobacter jejuni is the most common bacterial cause of enterocolitis in humans, leading to diarrhoea and chronic extraintestinal diseases. Although probiotics are effective in preventing other enteric infections, beneficial microorganisms have not been extensively studied with C. jejuni. The aim of this study was to delineate the ability of selected probiotic Lactobacillus strains to reduce epithelial cell invasion by C. jejuni. Human colon T84 and embryonic intestine 407 epithelial cells were pretreated with Lactobacillus strains and then infected with two prototypic C. jejuni pathogens. Lactobacillus helveticus, strain R0052 reduced C. jejuni invasion into T84 cells by 35–41%, whereas Lactobacillus rhamnosus R0011 did not reduce pathogen invasion.
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volume 300-1, p.146
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Research Letters cover the following subject categories:
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Biotechnology
Environmental microbiology; plant-microbe interactions
Eukaryotic cells
Evolution, taxonomy and typing
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Genetics and molecular biology
Genomics and bioinformatics
Pathogenicity including veterinary microbiology
Physiology and biochemistry
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