FEMS Immunology and Medical MicrobiologyLatest Issue | Online Early | The Publisher | Editorial Board
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Chief Editor: Patrik Bavoil
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Acces freely here the latest thematic issue on
NEGLECTED TROPICAL DISEASES
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Highlight: Borrelia burgdorferi PlzA is a c-di-GMP-binding protein
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The Borrelia burgdorferi Rrp1 protein is a diguanylate cyclase that controls a regulon consisting of ˜10% of the total genome. Because Rrp1 lacks a DNA-binding domain, its regulatory capability is most likely mediated through the production of bis-(3'–5')-cyclic dimeric GMP (c-di-GMP). C-di-GMP binds to and activates the regulatory activity of proteins that harbor a PilZ domain. The occurrence of a PilZ domain within a protein is not in and of itself sufficient to convey c-di-GMP binding, as other structural aspects of the protein are important in the interaction. ... this study is the first to identify a c-di-GMP effector molecule in a spirochete and provides additional evidence for the existence of a complete c-di-GMP regulatory network in the Lyme disease spirochete, B. burgdorferi. More
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Vol. 58 p.285
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Identification and molecular characterization of a cyclic-di-GMP effector protein, PlzA (BB0733): additional evidence for the existence of a functional cyclic-di-GMP regulatory network in the Lyme disease spirochete, Borrelia burgdorferi
John C. Freedman , Elizabeth A. Rogers, Jessica L. Kostick, Hongming Zhang, Radha Iyer, Ira Schwartz and Richard T. Marconi
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The editors of FEMS Immunology and Medical Microbiology aim to publish outstanding primary Research Articles and MiniReviews reporting on hypothesis-driven studies relating to infection, infection control and their molecular and cellular correlates. The infection typically involves that of humans or animals by microorganisms of all classes, i.e. viruses, bacteria, fungi or protozoa. The scientific approaches of these studies correspond broadly to the fields of immunology, medical microbiology, cell biology (of infectious diseases), and the biochemistry, molecular biology and genetics of pathogens. These include prominently the overlapping subspecialties of molecular and cellular microbial pathogenesis, host innate and adaptive immune responses to infection, "-omics" of pathogens and/or of the infected host, and modeling of the infection or disease (from biomathematical to in vitro to animal modeling). The Journal will also consider outstanding vaccine-related studies and molecular diagnostic and epidemiology studies that are focused on the infectious agent or the infection process.
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